Redheads, as they say, wear the map of Ireland all over their faces. Sorry, ginger-haired English Prince Harry. Ireland has the highest per capita percentage of redheads in the world -- anywhere from 10 to 30 percent, according to Eupedia...
And that's despite the known tendency of such people to avoid spending days in the sun, a factor known to initiate cellular changes leading to skin cancer. So, physicians treating people with red hair or a tendency to freckle, or whose parents did, have long been aware that something was up. Then, they sequenced the genes of the tumors taken from those patients for evidence of "somatic" mutations. Somatic mutations are changes to the underlying germline genes that exist only in the tumor sample and are therefore thought to play some role in cancer initiation or growth.
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